I agree it is disappointing to see valuable content behind a paywall, which is why I have never and will never do so with my formal essays. Same goes for restricting comments to paid subscribers. It is far more important to me for people to be able to access the content and participate in the communal discussion than to make a buck.
I did want to make one point of clarification. el gato malo is not paywalling any of his content. He is just offering extra bonus goodies like the occasional cat memes to paid subscribers, and the funds will ultimately be used for the greater good, including feline :-)
Alex is a lost cause. Doubling-down on his petulant attack on Dr. Malone combined with his (pharmaceutically motivated?) blindness to the incontrovertible evidence of the efficacy of ivermectin has damaged his credibility and revealed his moral character for what it is. He has lost thousands of subscribers as a result and has had to restrict his comments to paid subscribers to keep the comments from getting clogged with those attempting to hold him accountable for the damage he has caused. I gave up on him and am glad he only got $6 from me before I canceled (before his notorious performance, incidentally).
It would appear that the rush to get on blogstack and monetize has become a crowded trade.
For content after rona I think it will be back to the future: the best poasters will be available for free to everyone, along with an open comments section. IMO it is in the latter where the most underrated value lies. Couple times a year you can shake the tip jar and find that people are generous sans the paywall.
Jan 21, 2022·edited Jan 21, 2022Liked by Hidden Markov Respecter
"It sends S1 fragments around the bloodstream (now known to be cytotoxic) and as soluble foreign proteins, soon get picked up on the radar of antigen-presenting cells (APCs) that will tell B-cells (with additional help) to make specific Igs to get rid of this menace."
This is my understanding also - in fact I saw one report where they found spike 14 days later in the serum.
Yet our local blood donation org is saying a 3 day wait is all that is required to clear the blood post-vax. Again: immunology 101 says it takes around a week to get Ab working on clearing weird proteins from the blood (???) wtf?
They go so far as to say "there is no difference between vax and unvaxed blood".
Commodifying doesn't mean we're buying....it. I just can't afford to, and will seek out the freebies as long as I can....I think the benefits of allowing 'just anyone' to comment outweigh the benefits of having a selected audience if only for one reason...money does not buy reason. Only open forums allow reason to the extent they allow all to have a voice regardless of their ability to pay.
"The game plan was that with these anchored S1 proteins waving around in the breeze, T-cells would notice and take an interest, as expansion of interested T-cell clones requires, at minimum, sustained long-term cell-to-cell contact with an infected cell"
You have got to be fecking kidding me!!?
Is this documented somewhere? I was thinking as the spike was generated in the cell that the proteases would do their thing as if a virus was replicating, and break up enough of the spikes to generate antigens for the MHC I/II to then present? Is that not what is happening? How? I cannot even. This is immunology 101 from the easiest books on the subject to read.
Amazing article. In this long and will written (and witty) post you've managed to shine a light on how much of a shit show it really is. I'll definitely be sharing this and absolutely appreciate that you keep your stuff free. Many kudos.
By the way, what do you believe is the mechanism at play behind the apparent increased likelihood of the fully vaccinated and boosted to get infected with omicron versus the unvaccinated/purebloods/vaccine free (as Igor Chudov terms the unvaccinated in his stack)?
Also: on more than one occasion now I have wanted to respond to a post or post a link to more info / data that disagrees / confirms with someone's substack article only to have my typed characters in the comment box pop up numerous "Comments are for subscribers only".
Dang. Talk about cutting off your nose to spite your face.
Berenson rags on Trump voters too, a sure sign he's rolling in new money...
Oh you might know this: does your body stop creating new T cells before birth? Just a guy and I were discussing his autoimmune hypothesis and I suggested we create new T cells into our 40s or so, based on a study I found when looking into this. His thinking is we create our T cells pre-birth and they proliferate (?) to create new ones.
Looking through the 3-4 immunology books I have now, they all discuss T cell negative and positive selection, and CD4/8 differentiation, but none of them actually say anything about what period of our lives T cells are generated.
Is it known? I was kinda floored to discover thymus function knowledge is only 50 years old or so.
Thanks!
(Just scrolled down to ask this after your knowledge admission and wow, long post. Might have a few more comments to come haha)
The internet functions as a medium to endlessly examine the minutiae of the ongoing collapse of ...everything. After 15 years of consuming all of this I now understand that it is completely useless...in fact less than useless as it simply perpetuates the collapse.
The most important aspect of all this is that a growing number of people are able to make a living exploring the minutiae ad nauseum so I guess thats a good thing...?
I agree it is disappointing to see valuable content behind a paywall, which is why I have never and will never do so with my formal essays. Same goes for restricting comments to paid subscribers. It is far more important to me for people to be able to access the content and participate in the communal discussion than to make a buck.
I did want to make one point of clarification. el gato malo is not paywalling any of his content. He is just offering extra bonus goodies like the occasional cat memes to paid subscribers, and the funds will ultimately be used for the greater good, including feline :-)
https://boriquagato.substack.com/p/bad-cattitude-to-add-paid-option
Alex is a lost cause. Doubling-down on his petulant attack on Dr. Malone combined with his (pharmaceutically motivated?) blindness to the incontrovertible evidence of the efficacy of ivermectin has damaged his credibility and revealed his moral character for what it is. He has lost thousands of subscribers as a result and has had to restrict his comments to paid subscribers to keep the comments from getting clogged with those attempting to hold him accountable for the damage he has caused. I gave up on him and am glad he only got $6 from me before I canceled (before his notorious performance, incidentally).
Nice piece.
It would appear that the rush to get on blogstack and monetize has become a crowded trade.
For content after rona I think it will be back to the future: the best poasters will be available for free to everyone, along with an open comments section. IMO it is in the latter where the most underrated value lies. Couple times a year you can shake the tip jar and find that people are generous sans the paywall.
thanks a lot for your elucidation, really helpful, like your <sarc> too.
"It sends S1 fragments around the bloodstream (now known to be cytotoxic) and as soluble foreign proteins, soon get picked up on the radar of antigen-presenting cells (APCs) that will tell B-cells (with additional help) to make specific Igs to get rid of this menace."
This is my understanding also - in fact I saw one report where they found spike 14 days later in the serum.
Yet our local blood donation org is saying a 3 day wait is all that is required to clear the blood post-vax. Again: immunology 101 says it takes around a week to get Ab working on clearing weird proteins from the blood (???) wtf?
They go so far as to say "there is no difference between vax and unvaxed blood".
(Can you see this image? I screenshotted their response: https://cdn.substack.com/image/fetch/w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb3bf8d54-768f-4e3d-87cb-b17dd932189d_718x432.jpeg)
Commodifying doesn't mean we're buying....it. I just can't afford to, and will seek out the freebies as long as I can....I think the benefits of allowing 'just anyone' to comment outweigh the benefits of having a selected audience if only for one reason...money does not buy reason. Only open forums allow reason to the extent they allow all to have a voice regardless of their ability to pay.
Ability to think should be the only requisite.
"The game plan was that with these anchored S1 proteins waving around in the breeze, T-cells would notice and take an interest, as expansion of interested T-cell clones requires, at minimum, sustained long-term cell-to-cell contact with an infected cell"
You have got to be fecking kidding me!!?
Is this documented somewhere? I was thinking as the spike was generated in the cell that the proteases would do their thing as if a virus was replicating, and break up enough of the spikes to generate antigens for the MHC I/II to then present? Is that not what is happening? How? I cannot even. This is immunology 101 from the easiest books on the subject to read.
Amazing article. In this long and will written (and witty) post you've managed to shine a light on how much of a shit show it really is. I'll definitely be sharing this and absolutely appreciate that you keep your stuff free. Many kudos.
By the way, what do you believe is the mechanism at play behind the apparent increased likelihood of the fully vaccinated and boosted to get infected with omicron versus the unvaccinated/purebloods/vaccine free (as Igor Chudov terms the unvaccinated in his stack)?
Also: on more than one occasion now I have wanted to respond to a post or post a link to more info / data that disagrees / confirms with someone's substack article only to have my typed characters in the comment box pop up numerous "Comments are for subscribers only".
Dang. Talk about cutting off your nose to spite your face.
Berenson rags on Trump voters too, a sure sign he's rolling in new money...
Oh you might know this: does your body stop creating new T cells before birth? Just a guy and I were discussing his autoimmune hypothesis and I suggested we create new T cells into our 40s or so, based on a study I found when looking into this. His thinking is we create our T cells pre-birth and they proliferate (?) to create new ones.
Looking through the 3-4 immunology books I have now, they all discuss T cell negative and positive selection, and CD4/8 differentiation, but none of them actually say anything about what period of our lives T cells are generated.
Is it known? I was kinda floored to discover thymus function knowledge is only 50 years old or so.
Thanks!
(Just scrolled down to ask this after your knowledge admission and wow, long post. Might have a few more comments to come haha)
The internet functions as a medium to endlessly examine the minutiae of the ongoing collapse of ...everything. After 15 years of consuming all of this I now understand that it is completely useless...in fact less than useless as it simply perpetuates the collapse.
The most important aspect of all this is that a growing number of people are able to make a living exploring the minutiae ad nauseum so I guess thats a good thing...?